Abstract
A series of thiazole benzenesulfonamide-substituted 3-pyridylethanolamines was prepared and evaluated for their human beta3 adrenergic receptor agonist activity. Incorporation of aryl and heteroaryl substitution in the 4-position of the thiazole ring resulted in a number of highly potent and selective beta3 agonists. Results of preliminary in vivo evaluation of several of these compounds is described.
MeSH terms
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Adrenergic beta-3 Receptor Agonists*
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Adrenergic beta-Agonists / chemical synthesis*
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Adrenergic beta-Agonists / pharmacology
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Animals
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Benzenesulfonamides
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CHO Cells
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Cricetinae
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Ethanolamines / chemical synthesis*
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Humans
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis*
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Thiazoles / chemical synthesis*
Substances
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Adrenergic beta-3 Receptor Agonists
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Adrenergic beta-Agonists
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Ethanolamines
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Sulfonamides
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Thiazoles